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The differences between Down syndrome and Klinefelter syndrome are as follows: Down syndrome: It is caused by the extra 21 chromosome that is present in an offspring. Instead of having the usual XY chromosome pattern that most males have, these men have an XXY pattern. • Down Syndrome Trisomy 21 (three) • Turner Syndrome (XO) • Klinefelter Syndrome (XXY) Polygenic inheritance In most cases, many genes interact to produce a particular characteristic. However, the syndromic specificity and developmental trajectories associated with EF difficulties in these groups are poorly understood. Because Klinefelter syndrome falls on a spectrum, though there are many similarities, people with Klinefelter syndrome often learn, think and interact differently than others. The correlations for stature between parents and grown-up offspring in 90 normal males and 116 normal females have been compared with similar correlations obtained in 27 adult males with Klinefelter's syndrome, 33 adult females with Turner's syndrome and in 75 adult patients with Down's syndrome. This page further explores this syndrome and its causes, symptoms, and treatment options. Down syndrome — also known as trisomy 21 — is a condition in which a person is born with extra genetic material from chromosome 21, one of the 23 human chromosomes. Klinefelter syndrome: Expanding the phenotype and identifying new research directions. Annales … Abstract. Where comparisons could be made, termination rates were similar in … Often, symptoms are subtle and subjects do not realize they are affected. Down syndrome, also called Trisomy 21, is a developmental disorder which is caused by an extra copy of chromosomes 21. Turner syndrome is characterized by complete or partial absence of one of the two X chromosomes. Three examples of genetic disorders are Down syndrome, Turner syndrome, and Breast/Ovarian cancer. An individual with Swyer syndrome (46, XY) differs from an individual with Klinefelter syndrome (47, XXY) because an individual with Klinefelter syndrome has a functional SRY gene on his Y chromosome, whereas an individual with Swyer syndrome does not. Plotton, I., Brosse A., & Lejeune, H. (2010). Between 1-400 to 1-650 males are born with Klinefelter syndrome. Klinefelter syndrome, also known as the XXY condition, is a term used to describe males who have an extra X chromosome in most of their cells. Klinefelter syndrome, also known as XXY syndrome, is a condition in boys and men that’s caused by an extra X chromosome. Females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY). Turner's syndrome and Klinefelter's syndrome involve abnormalities in the X sex chromosome. Normally, males have 46 chromosomes with one X and 1 Y chromosome. ; About one of every 500 males has an extra X chromosome, but many don't have any symptoms. It is named after John Langdon Down who is a British physician who described the syndrome in 1866 (Living With Down Syndrome). Klinefelter syndrome may be confused with the genetic condition Kallmann syndrome. In 1959, Down syndrome was shown to be associated with an extra chromosome in the G group 1; Klinefelter syndrome was associated with an extra X chromosome 2; and a case of double aneuploidy, a 48,XXY,G + male, was reported. Klinefelter syndrome is caused by the addition of an X chromosome. Executive functions (EF) are thought to be impaired in Down syndrome (DS) and sex chromosome trisomy (Klinefelter and Trisomy X syndromes; +1X). This possibility occurs as males with Klinefelter syndrome and Kallmann syndrome can have delayed or absent puberty and infertility concerns. 49 years experience Developmental and Behavioral Pediatrics. Genetics in Medicine, 5(6), 460-468. Down syndrome, Turner syndrome, and Klinefelter syndrome constitute the most common chromosomal abnormalities encountered by primary care physicians. Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. A 33-year-old member asked: what is the difference between down syndrome and turner syndrome? Klinefelter syndrome, also known as the XXY condition, is a term used to describe males who have an extra X chromosome in most of their cells. British physician who described the syndrome in 1866 ( Living with Down syndrome, also called trisomy 21, a... Usually occur in pairs, with one copy inherited from a person ’ mother... 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